Vous êtes ici

BPCO, respiration et sommeil

F. Chabot,*, T. Perez,*, M. Decavèle


[1] Purves D, Augustine GJ, Fitzpatrick D, Katz LC, LaMantia AS, McNamara JO, et al. Neuroscience, 2nd Ed. Sunderland, Sinauer, 2001.

[2] Phillipson EA. Control of breathing during sleep. Am Rev Respir Dis 1978;118:909-39.

[3] Berthon-Jones M, Sullivan CE. Ventilatory and arousal responses to hypoxia in sleeping humans. Am Rev Respir Dis 1982;125:632-9.

[4] Gothe B, Altose MD, Goldman MD, Cherniack NS. Effect of quiet sleep on resting and CO2-stimulated breathing in humans. J Appl Physiol: Respirat Environ Exercise Physiol 1981;50:724-30.

[5] White DP, Weil JV, Zwillich CW. Metabolic rate and breathing during sleep. J Appl Physiol 1985;59:384-91.

[6] Parmeggiani PL. Physiologic regulation in sleep. In: Kryger MH, Roth T, Dement WC (Eds): Principles and Practice of Sleep Medicine, 4th Ed. Philadelphia, Elsevier Health Sciences, 2005.

[7] Ballard RD, Clover CW, Sush BY. Infl uence of sleep on respiratory function in emphysema. Am J Respir Crit Care Med 1995;151:945-51.

[8] Collop N. Sleep and sleep disorders in chronic obstructive pulmonary disease. Respiration 2010;80:78-86.

[9] Becker HF, Piper AJ, Flynn WE, McNamara SG, Grunstein RR, Peter JH, et al. Breathing during sleep in patients with nocturnal desaturation. Am J Respir Crit Care Med 1999;159:112- 8.

[10] Midgren B. Oxygen desaturation during sleep as a function of the underlying respiratory disease. Am Rev Respir Dis 1990;141:43-6.

[11] Sanders MH, Newman AB, Haggerty CL, Redline S, Lebowitz M, Samet J, et al. Sleep and sleep- disordered breathing in adults with predominantly mild obstructive airway disease. Am J Respir Crit Care Med 2003;167:7–14.

[12] Little SA, Elkholy MM, Chalmers GW, Farouk A, Patel KR, Thomson NC. Predictors of nocturnal oxygen desaturation in patients with COPD. Respir Med 1999;93:202-7.

[13] Zanchet RC, Viegas CA. Nocturnal desaturation: predictors and the effect on sleep patterns in patients with chronic obstructive pulmonary disease and concomitant mild daytime hypoxemia. J Bras Pneumol 2006;32:207–12.

[14] Trask CH, Cree EM. Oximeter studies on patients with chronic obstructive emphysema, awake and during sleep. N Engl J Med 1962;266:639-42.

[15] Lewis CA, Eaton TE, Fergusson W, Whyte KF, Garrett JE, Kolbe J. Home overnight pulse oximetry in patients with COPD: more than one recording may be needed. Chest 2003;123:1127-33.

[16] Flenley DC. Sleep in chronic obstructive lung disease. Clin Chest Med 1985;6:651-61.

[17] DeMarco FJ Jr, Wynne JW, Block AJ, Boysen PG, Taasan VC. Oxygen desaturation during sleep as a determinant of the ‘Blue and Bloated’ syndrome. Chest 1981;79:621–5.

[18] Chaouat A, Naeije R, Weitzenblum E. Pulmonary hypertension in COPD. Eur Respir J 2008;32:1371-85.

[19] Fletcher EC, Luckett RA, Goodnight-White S, Miller CC, Qian W, Costarangos-Galarza C. A double-blind trial of nocturnal supplemental oxygen for sleep desaturation in patients with chronic obstructive pulmonary disease and a daytime PaO2 above 60 mmHg. Am Rev Respir Dis 1992;145:1070-6.

[20] Chaouat A, Bugnet AS, Kadaoui N, Schott R, Enache I, Ducoloné A, et al. Severe pulmonary hypertension and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005;172:189-94.

[21] Weitzenblum E, Chaouat A. Severe pulmonary hyper-tension in COPD: is it a distinct disease? Chest 2005;127:1480-2. [22] Mulloy E, McNicholas WT. Ventilation and gas exchange during sleep and exercise in patients with severe COPD. Chest 1996;109:387-94.

[23] Ballard RD, Irvin CG, Martin RJ, Pak J, Pandey R, White DP. Infl uence of sleep on lung volume in asthmatic patients and normal subjects. J Appl Physiol 1990;68:2034-41.

[24] McNicholas WT. Impact of sleep in COPD. Chest 2000;117:48S–53S. [25] Douglas NJ, White DP, Pickett CK, Weil JV, Zwillich CW. Respiration during sleep in normal man. Thorax 1982;37:840-4.

[26] Hudgel DW, Martin RJ, Johnson BJ, Hill P. Mechanics of the respiratory system and breathing pattern during sleep in normal humans. J Appl Physiol: Respirat Environ Exercise Physiol 1984;56:133–7.

[27] Wiegand L, Zwillich CW, White DP. Sleep and the ventilatory response to resistive loading in normal men. J Appl Physiol 1998;64:1186-95.

[28] McNicholas WT. Impact of sleep in respiratory failure. Eur Respir J 1997;10:920–33.

[29] Juan G, Calverley P, Talamo C, Schnader J, Roussos C. Effect of carbon dioxide on diaphragmatic function in human beings. N Engl J Med 1984;310:874–9.

[30] Hetzel MR, Clark TJH. Comparison of normal and asthmatic circadian rhythms in peak expiratory fl ow rate. Thorax 1980;35:732–8.

[31] Van Manen JG, Bindels PJ, Dekker FW, Bottema BJ, Van der Zee JS, Ijzermans CJ, Schade E. The infl uence of COPD on healthrelated quality of life independent of the infl uence of comorbidity. J Clin Epidemiol 2003;56:1177–84.

[32] Fletcher EC, Miller J, Divine GW, Fletcher JG, Miller T. Nocturnal oxyhemoglobin desaturation in COPD patients with arterial oxygen tensions above 60 mmHg. Chest 1987;92:604-8.

[33] Scott AS, Baltzman MA, Chan R, Wolkove N. Oxygen desaturation during a 6 min walk test is a sign of nocturnal hypoxemia. Can Respir J 2011;18:333-7.

[34] Heijdra YF, Dekhuijzen PN, van Herwaarden CL, Folgering HT. Nocturnal saturation improves by target-fl ow inspiratory muscle training in patients with COPD. Am J Respir Crit Care Med 1996;153:260-5.

[35] Corda L, Novali M, Montemurro LT, La Piana GE, Redolfi S, Braghini A, et al. Predictors of nocturnal oxyhemoglobin desaturation in COPD. Respir Physiol Neurobiol 2011;179:192-7.

[36] Fletcher EC, Luckett RA, Miller T, Costarangos C, Kutka N, Fletcher JG. Pulmonary vascular hemodynamics in chronic lung disease patients with and without oxyhemoglobin desaturation during sleep. Chest 1989;95:757–64.

[37] Chaouat A, Weitzenblum E, Kessler R, Charpentier C, Ehrhart M, Levi-Valensi P, et al. Sleep-related O2 desaturation and daytime pulmonary haemodynamics in COPD patients with mild hypoxaemia. Eur Respir J 1997;10:1730–5.

[38] Chaouat A, Weitzenblum E, Kessler R, Schott R, Charpentier C, Levi-Valensi P, et al. Outcome of COPD patients with mild daytime hypoxaemia with or without sleep-related oxygen desaturation. Eur Respir J 2001;17:848–55.

[39] Tirlapur VG, Mir MA. Nocturnal hypoxemia and associated electrocardiographic changes in patients with chronic obstructive airways disease. N Engl J Med 1982;306:125-30.

[40] Shepard JW, Schweitzer PK, Kellar CA, Chun DS, Dolan GF. Myocardial stress: exercise versus sleep in patients with COPD. Chest 1984;86:366-74.

[41] Fletcher EC, Donner CF, Midgren B, Zielinski J, Levi-Valensi P, Braghiroli A, et al. Survival in COPD patients with a daytime PaO2 greater than 60 mm Hg with and without nocturnal oxyhemoglobin desaturation. Chest 1992;101:649-55.

[42] Douglas NJ. Nocturnal hypoxemia in patients with chronic obstructive pulmonary disease. Clin Chest Med 1992;13:523-32.

[43] Buysse DJ, Reynolds III CF, Monk TH, Berman SR, Kupfer DJ. The Pittsburgh Sleep Quality Index: A new instrument for psychiatric practice and research. J Psychiatr Res 1989;28:193-213.

[44] Cormick W, Olson LG, Hensley MJ, Saunders NA. Nocturnal hypoxaemia and quality of sleep in patients with chronic obstructive lung disease. Thorax 1986;41:846-54.

[45] Scharf SM, Maimon N, Simon-Tuval T, Bernhard-Scharf BJ, Reuveni H, Tarasiuk A. Sleep quality predicts quality of life in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2010;6:1-12.

[46] Kwon JS, Wolfe LF, Lu BS, Kalhan R. Hyperinfl ation is associated with lower sleep effi ciency in COPD with co-existent obstructive sleep apnea. COPD 2009;6:441-5.

[47] Krachman SL, Chatila W, Ubaldo JM, Permut I, D’Alonzo GE, Gaughan JP, et al. Physiologic Correlates of Sleep Quality in Severe Emphysema. COPD 2011;8:182-8.

[48] Krachman SL, Chatila W, Martin UJ, Nugent T, Crocetti J, Gaughan J, et al ; for the National Emphysema Treatment Trial Research Group. Effects of Lung Volume Reduction Surgery on Sleep Quality and Nocturnal Gas Exchange in Patients With Severe Emphysema. Chest 2005;128:3221–8.

[49] Lo Coco D, Mattaliano A, Lo Coco A, Randisi B. Increased frequency of restless legs syndrome in chronic obstructive pulmonary disease patients. Sleep Med 2009;10:572-6.

[50] Cavalcante AG, De Bruin PF, De Bruin VM, Pereira ED, Cavalcante MM, Nunes DM, et al. Restless legs syndrome, sleep impairment, and fatigue in chronic obstructive pulmonary disease. Sleep Med 2012;13:842-7.

[51] Zhang MW, Ho RC, Cheung MW, Fu E, Mak A. Prevalence of depressive symptoms in patients with chronic obstructive pulmonary disease: a systematic review, meta-analysis and metaregression. Gen Hosp Psychiatry 2011;33:217-23.

[52] Ito K, Kawayama T, Fukushima N, Matsunaga K, Edakuni N, Ushimura N, Hoshino T. Depression, but not sleep disorders is an independant factor affecting exacerbatiosn and hospitalization in patients with chronic obstructive pulmonary disease. Respirology 2012;17:940-9.

[53] Donohue JF, Fogarty C, Lötvall J, Mahler DA, Worth H, Yorgancioglu A, et al; INHANCE Study Investigators. Once-daily bronchodilators for chronic obstructive pulmonary disease: indacaterol versus tiotropium. Am J Respir Crit Care Med 2010;182:155-62.

[54] Agusti A, Hedner J, Marin JM, Barbe F, Cazzola M, Rennard S. Night-time symptoms: a forgotten dimension of COPD. Eur Respir Rev 2011;20:121,883-94.

[55] Owens RL. Supplemental oxygen needs during sleep. Who benefi ts? Respir Care 2013;58:32-44.

Auteurs correspondants

*Auteurs correspondants.
Adresses e- mail : f.chabot@chu-nancy.fr (F. Chabot) ; tperez@chru-lille.fr. (T. Perez).


F. Chabot1,*, T. Perez2,*, M. Decavèle3

1Département de pneumologie, CHU Nancy, hôpitaux de Brabois, rue du Morvan, 54500 Vandoeuvre-Lès-Nancy, France
2Clinique des maladies respiratoires, Centre de compétence des maladies pulmonaires rares, hôpital Calmette, Université Lille-Nord de France, boulevard du Professeur-Jules-Leclercq, CHRU Lille, 59037 Lille Cedex, France
3Pneumologie Ile-de-France, DESC réanimation médicale ; Service de pneumologie et réanimation, Groupe hospitalier Pitié-Salpêtrière, 47-83 boulevard de l’Hôpital, 75013 Paris, France

Liens d'intérêts

  • F. Chabot : Au cours des cinq dernières années, F. Chabot a perçu des honoraires ou fi nancements pour participation à des congrès (laboratoires Boehringer-Ingelheim, Chiesi, GSK, Novartis), actions de formation (laboratoires AstraZeneca, Boehringer-Ingelheim, Chiesi, GSK), participations à des groupes d’experts (laboratoires Almirall , Boehringer-Ingelheim, Chiesi).
  • T. Perez : Au cours des 5 dernières années T. Perez a perçu des fi nancements pour participation à des congrès par les laboratoires Novartis, Boehringer Ingelheim, Takeda, Chiesi. Il a participé à des groupes d’experts pour les laboratoires Novartis, Pierre Fabre, Takeda, Almirall, Chiesi et a été investigateur d’études cliniques promues par les laboratoires Novartis, Pierre Fabre et Almirall.
  • M. Decavèle a déclaré n’avoir aucun lien d’intérêts pour cet article.